Luis Suarez is set to miss two weeks with a knee problem. He played the full match in the 1-1 weekend draw at Atletico Madrid but will undergo stem-cell treatment to address an issue in his right knee.
Netherlands goalkeeper Jasper Cillessen will join Suárez on the sidelines for up to three weeks after reporting a thigh issue in the warm-up on Saturday.
Arthur is also out of the midweek trip to Eindhoven, having suffered an adductor strain.
Meanwhile, Ivan Rakitic and Philippe Coutinho are back in the squad in a welcome boost to head coach Ernesto Valverde.
Barcelona have already qualified for the Champions League last 16 and will seal first place in Group B with a win over PSV, while a draw will be enough if Inter do not beat Tottenham.