Leaders Manchester City are looking for a third straight victory, while Chelsea are aiming to build on their 5-0 triumph over Huddersfield Town.
The Blues are unbeaten in seven PL fixtures against reigning PL champions and can now become only the third team to win four such matches in a row, after Liverpool and Man City.
Chelsea have no major injuries to contend with and Guardiola is expecting a very challenging game.
Here is possible line-up for Chelsea