Michael Oliver and wife Lucy were subjected to vile threats after Arsenal's defeat to Leicester.
Michale took charge of the Gunners’ defeat at Leicester City , while his wife Lucy oversaw Arsenal Women away to Brighton.
At the King Power Stadium, an early red card for Ainsley Maitland-Niles angered many fans of the North London club but some took it too far.
BBC broadcaster Jacqui Oatley tweeted to show the shocking abuse sent to Ms Oliver following Arsenal's loss at Leicester.
She posted: "Michael Oliver refereed Arsenal men (lost 3-0), while wife Lucy Oliver refereed Arsenal Women (won 4-0 and the title).
"Both did their jobs with utmost integrity as ever. Lucy was sent this vile tweet afterwards."
Oatley called on Twitter to take action over the abuse after an apparent Arsenal fan claimed "Michael Oliver deserves to be shot in the head".
The tweet added: "Michael and Lucy Oliver deserve nothing but the worst. Karma will catch up with these two disgraceful cheating c****."
Another Twitter user sent shocking sexist abuse towards Oatley after reporting the post.
A reply to her tweet read: "F*** off you s***. Get back to the kitchen. Women's football aint s***."
Following the defeat Arsenal remain in fifth in the Premier League table after their third consecutive defeat.